NOTCH1 and Cardiac Cells

Neonatal cardiomyocytes. Ps1415, via Wikimedia Commons.

A study from Nationwide Children’s Hospital provides novel insights into how mutations in the NOTCH1 gene may lead to abnormal differentiation and proliferation of cardiomyocytes in humans. The findings provide some insight on the disease mechanisms underlying severe types of congenital heart defects where the left side of the heart is not well formed, such as hypoplastic left heart syndrome.

Read more at Pediatrics Nationwide: New Insights into the Role of the NOTCH1 Gene in Congenital Heart Defects.