Addiction and depression are mental health disorders with biological origins in the brain. They are also public health challenges with serious consequences. Unfortunately, today’s treatments for addiction and depression are inadequate for many patients. Continued basic research is needed in order to better understand these disorders and formulate more effective therapeutics. In an article for the Society of Neuroscience’s Annual Report, I take a look at SfN past president Eric Nestler’s research into how the brain changes at the molecular level in response to addiction and depression. Read the article here: Unlocking the Molecular Mysteries of Addiction and Depression .